Neurogen Corporation (Nasdaq: NRGN) announced that, as planned, it commenced a Phase 2/3 clinical trial in chronic insomnia patients with the Company's insomnia agent, adipiplon and that, based upon reports from initial dosing of a higher than anticipated rate of unwanted next day effects, the Company has suspended dosing in the study. Neurogen believes that the bilayer tablet formulation of adipiplon being used in the study may not be performing as expected.
Publ.Date : Tue, 15 Jul 2008 00:00:00 PDT
A study in the July 1 issue of the journal Sleep provides visual evidence of the severe structural damage that occurs in numerous regions of the brain in people with obstructive sleep apnea (OSA). Results show that OSA patients have extensive alterations in "white matter," nerve tissue in the brain containing fibers that are insulated with myelin - a white, fatty sheath.
Publ.Date : Tue, 08 Jul 2008 01:00:00 PDT
Two studies in the July 1 issue of the journal Sleep analyze menopausal sleep problems, finding that complaints may differ according to the stage of menopausal transition and the ethnicity of the woman, and identifying risk factors that may predict sleep problems at any stage of menopause. A multi-ethnic study of more than 3,000 women shows that the odds of having trouble falling asleep and staying asleep increase through the menopausal transition.
Publ.Date : Tue, 08 Jul 2008 01:00:00 PDT
Treating pediatric obstructive sleep apnea (OSA) with either orthodontic expansion or adenotonsillectomy improves symptoms, but most young children need both treatments to have complete resolution of OSA symptoms, according to a study in the July 1 issue of the journal Sleep.
Publ.Date : Tue, 08 Jul 2008 00:00:00 PDT
A study in the July 1 issue of the journal Sleep shows that episodes of sleep-disordered breathing accompanied by mild oxygen desaturations of as little as two percent are associated with hyperglycemia. Adults with 11 or more apnea-hypopnea events per hour with an oxygen desaturation of 2.0 percent to 2.9 percent had an adjusted cumulative odds ratio of 1.41 for impaired fasting glucose or diabetes.
Publ.Date : Tue, 08 Jul 2008 00:00:00 PDT
Difficulty falling asleep and staying asleep increase as women go through menopause according to research by Rush University Medical Center. Waking up earlier than planned also increases through late perimenopause but decreases when women become postmenopausal. The study is published in the July 1 issue of the journal SLEEP.
Publ.Date : Wed, 02 Jul 2008 00:00:00 PDT
A new report published in the open-access journal PLoS Biology examines the effect that light has on humans and animals. Most of us are familiar with how light affects the growth and development of plants (phototropism, for example, describes how plants grow towards light), but researcher Nathalie Hoang and colleagues set out to explore light's impact on humans and mammals.
Publ.Date : Tue, 01 Jul 2008 00:00:00 PDT
Lack of both the fragile X syndrome gene and one that is related could account for sleep problems associated with the disorder, which is the common cause of inherited mental impairment, said a consortium of researchers led by scientists at Baylor College of Medicine in Houston. Their findings appear in a report in the current issue of the American Journal of Human Genetics.
Publ.Date : Sat, 28 Jun 2008 07:00:00 PDT
Researchers at the University of Pennsylvania School of Medicine have shown that the unfolded protein response, which is a reaction to stress induced by sleep deprivation, is impaired in the brains of old mice. The findings suggest that inadequate sleep in the elderly, who normally experience sleep disturbances, could exacerbate an already-impaired protective response to protein misfolding that happens in aging cells.
Publ.Date : Sat, 28 Jun 2008 00:00:00 PDT
What's the biggest pain in your life? Credit card debt? High gas prices? While these problems are extremely bothersome, a new survey from the makers of DR. SCHOLL'SŪ reveals that the physical pain suffered by people with knee and lower back pain is also at the top of the list. The survey shows that knee and lower back pain pervade many aspects of respondents' lives - and that's only the beginning of the story.
Publ.Date : Fri, 27 Jun 2008 04:00:00 PDT
Vanda Pharmaceuticals Inc. (Nasdaq: VNDA) (Vanda) announced positive top-line results from a Phase III trial showing that its investigational drug candidate, tasimelteon (VEC-162), a novel melatonin agonist, met the primary endpoint of the trial and significantly improved sleep in adult patients with chronic insomnia.
Publ.Date : Fri, 27 Jun 2008 02:00:00 PDT
Covidien (NYSE: COV, BSX: COV), a leading global healthcare products company, announced the latest advance in its "Unite to Treat Sleep Apnea" initiative, an integrated program connecting physicians, sleep labs, treatment providers and patients to improve the diagnosis and treatment of those afflicted with obstructive sleep apnea.
Publ.Date : Sun, 22 Jun 2008 09:00:00 PDT
More than half of all older adults complain about having difficulties sleeping. Most don't bother seeking treatment. Those who do usually turn either to medications, which can lead to other health problems, or behavior therapies, which are costly and often not available close to home. Now, UCLA researchers report that practicing tai chi chih, the Westernized version of a 2,000-year-old Chinese martial art, promotes sleep quality in older adults with moderate sleep complaints.
Publ.Date : Sun, 22 Jun 2008 00:00:00 PDT
For many women the secret of a good night's sleep is a happy marriage, according to a study in US. Researchers at the University of Pittsburgh studied nearly 2,000 middle-aged women across the country. Specifically they recorded the subjects' own assessment of their marital happiness and compared this with how well they slept.
Publ.Date : Sat, 21 Jun 2008 10:00:00 PDT
People who don't sleep enough are more likely to indulge in risk-taking behaviour, a new study suggests. Earlier studies have shown that acute, severe sleep deprivation increases risk taking. But a team from Harvard Medical School and Walter Reed Army Institute of Research in Silver Spring, Maryland, has now investigated the effect of chronic deprivation on such behaviour.
Publ.Date : Sat, 21 Jun 2008 09:00:00 PDT
The average company loses the equivalent of 2.5 weeks of paid work from everyone it employs due to the effects of insomnia and sleep loss, a study suggests. Researchers from Tufts New England Medical Centre in Boston and the private research company Alertness Solutions looked at the link between sleep problems and productivity in workers from four separate US companies including an airline, a pharmaceutical company, a manufacturer and a law firm.
Publ.Date : Sat, 21 Jun 2008 08:00:00 PDT
Too little deep sleep may accelerate the physical decline associated with old age, a study suggests. A team from the University of Chicago has presented what it describes as the first evidence that reduced slow wave sleep contributes to the decline in human hormone growth secretion - a key factor in the muscle wastage and increased body fat seen in older people.
Publ.Date : Sat, 21 Jun 2008 07:00:00 PDT
Insomniacs who sleep fewer than five hours a night are five times more likely to suffer hypertension than people who sleep well, according to a major study that highlights the growing concerns over links between sleep problems and serious illness.
Publ.Date : Sat, 21 Jun 2008 06:00:00 PDT
Nearly a quarter of the population suffers nocturnal awakenings or "middle of the night insomnia", on a daily basis, according to major study. The survey of nearly 9,000 people also suggests that one person in three wakes in the middle of the night at least three times a week. Lead investigator Dr Maurice Ohayon of Stanford University's Sleep Epidemiology Research Centre, described the prevalence of night-time awakenings revealed by the research as "incredible".
Publ.Date : Sat, 21 Jun 2008 05:00:00 PDT
Bedtime restriction in an environment that promotes overeating and inactivity is accompanied by increased intake of calories from snacks. This behavior may contribute to the increased risk of weight gain and obesity associated with short sleep hours, according to a research abstrac presented at SLEEP 2008, the 22nd Annual Meeting of the Associated Professional Sleep Societies (APSS).
Publ.Date : Sun, 15 Jun 2008 02:00:00 PDT
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